Make your clinical, claims, and operational data AI-ready in weeks, fully inside your HIPAA perimeter.

NexusOne is the composable data layer for payers, providers, and life sciences. We unify your EHR, claims, policy admin, lab, clinical trial, and operational systems into one governed, AI-ready estate — in weeks, with no migration and no PHI leaving your environment. HIPAA and HITRUST certified.

Getting clinical and claims AI into production is a data problem, not a model problem

Your data lives across Epic or Cerner, a 20-year-old policy admin system, a half-built cloud data lake, a payer-side claims warehouse, and ten years of lab and imaging archives nobody wants to migrate. Every AI vendor's pitch starts the same way: move your PHI to our platform first.

Now add agents to the picture. Your Chief AI Officer deployed them against the same fragmented estate for prior auth, claims review, ambient documentation, and clinical decision support. Your CISO wants to know which PHI elements they touched. Your compliance team needs an audit trail on every prompt, every response, every human review, and every model version change. Your CFO wants per-agent FinOps before the inference bill arrives. And nobody has a kill switch for an agent that goes off-script in front of a clinician or a member.

The model was never the hard part. The context layer behind it, PHI lineage, identity, audit trail, human review, cost attribution, is what makes AI safe to put in front of a clinician, a member, or a regulator.

There’s a better way.

NexusOne keeps what works, fixes what doesn't, and connects your EHR, claims, clinical, and operational systems into a modern, governed estate that's ready for AI, without asking you for a long, expensive migration.

Turn your clinical, claims, and operational data into an asset for AI right away, not a migration project.

NexusOne doesn't replace your EHR, your claims platform, your policy admin, or your cloud lake. It lays over them.

Your data estate today

Clinical, claims, lab, imaging, and operational data fragmented across EHR, policy admin, on-prem warehouses, and the cloud lake.

AI pilots run on de-identified sandbox extracts. Nothing reaches the bedside or the member workflow because the extracts aren't audit-defensible under HIPAA.

Every new use case (prior auth, FWA, ambient scribe, RWE) demands another point integration or another HIPAA review.

60–80% of data engineering time spent on Mirth interfaces, FHIR exports, broken nightly loads, and Hadoop upgrades.

PHI leaves your perimeter the moment a cloud LLM gets involved. Privacy officer says no, business case dies.

Agents run with no FinOps on tokens, no circuit breakers, no lineage for what they wrote to the chart or the claim.

Auditors and regulators flag PHI inconsistencies before your team does. MTTR for HEDIS, Stars, and quality reporting runs into weeks.

With NexusOne

One layer federates EHR, claims, policy admin, lab, imaging, RWE, and operational sources behind one catalog, one identity, one HIPAA-grade policy model.

AI serving with PHI lineage, audit trail, and human-review checkpoints that compliance and CMOs can inspect.

Inherit Epic, Cerner, Hadoop, Spark, and warehouse workloads as-is, without rewrites.

Patches, upgrades, and access policy run on the platform, not on your headcount.

PHI never leaves your VPC or your region. Sovereign AI inside the HIPAA boundary.

Per-agent FinOps, a central agent registry, automated circuit breakers, and lineage on every prompt, response, and write back to a chart or claim.

Automated lineage testing catches data quality failures before they hit reporting. MTTR drops from weeks to hours.

Power AI applications and use cases for health with NexusOne

Platform + People + Automation

Superior data technology

A composable, open data layer that lays over your existing EHR, claims, and cloud estate. Unified catalog, Iceberg storage, semantic layer over FHIR and clinical vocabularies, air-gapped governance, 100% open standards. Kubernetes-native, on-prem, cloud, or hybrid, the same architecture across every facility, plan, or site.

Forward-deployed engineers

Forward-deployed engineers who have built this inside regulated environments under HIPAA, HITRUST, and GxP. They sit with your clinical informatics, IT, and compliance teams in your environment, deploy alongside them, and deliver production AI outcomes against your highest-friction workflow, not slide decks.

AI/ML-enabled operations

One-click HDFS-to-Iceberg migration for clinical archives. Kafka-free CDC for claims and policy admin. FHIR and HL7 schema translation. Policy generation aligned to HIPAA minimum necessary. Dynamic agent governance with PHI redaction. Months of plumbing, done in minutes.

Built for the work your clinical, payer, and life sciences teams have to ship next quarter.

Prior Auth & Utilization Management

Ground prior auth and UM agents in member history, clinical guidelines, and policy. Full lineage on every approval or denial. PHI never leaves the plan.

Prior Auth & Utilization Management

Ground prior auth and UM agents in member history, clinical guidelines, and policy. Full lineage on every approval or denial. PHI never leaves the plan.

Claims, Fraud, Waste & Abuse

Catch FWA and improper-payment patterns in milliseconds against the entire claims history. No PHI shipped to a hosted inference API. Models run where the data lives.

Claims, Fraud, Waste & Abuse

Catch FWA and improper-payment patterns in milliseconds against the entire claims history. No PHI shipped to a hosted inference API. Models run where the data lives.

Ambient Clinical Documentation & CDS

A governed data layer behind ambient scribes and clinical decision support. Every prompt, every response, every human attestation logged and auditable. CMO and CMIO can defend any output.

Ambient Clinical Documentation & CDS

A governed data layer behind ambient scribes and clinical decision support. Every prompt, every response, every human attestation logged and auditable. CMO and CMIO can defend any output.

Quality, Stars & Regulatory Reporting

Automated lineage testing catches PHI and code quality failures before they hit HEDIS, Stars, MIPS, or state reporting. When regulators or auditors flag inconsistencies, MTTR drops from weeks to hours.

Quality, Stars & Regulatory Reporting

Automated lineage testing catches PHI and code quality failures before they hit HEDIS, Stars, MIPS, or state reporting. When regulators or auditors flag inconsistencies, MTTR drops from weeks to hours.

Real-World Evidence & Clinical Trials

Unify EHR, claims, lab, imaging, registry, and trial operations data into an RWE-ready, GxP-compatible semantic layer. Feed trial design, regulatory submissions, and post-market surveillance from the same governed estate.

Real-World Evidence & Clinical Trials

Unify EHR, claims, lab, imaging, registry, and trial operations data into an RWE-ready, GxP-compatible semantic layer. Feed trial design, regulatory submissions, and post-market surveillance from the same governed estate.

AI Agent Governance for Clinical and Member Workflows

Central registry for every clinical, member-facing, and back-office agent. Per-workflow FinOps. Identity federation that treats clinicians, members, and agents under one HIPAA policy. Circuit breakers and lineage on every write to a chart, claim, or member record.

AI Agent Governance for Clinical and Member Workflows

Central registry for every clinical, member-facing, and back-office agent. Per-workflow FinOps. Identity federation that treats clinicians, members, and agents under one HIPAA policy. Circuit breakers and lineage on every write to a chart, claim, or member record.

Achieve an AI-ready data layer in weeks, not years

5 hours

Deploy NexusOne, launch the control plane inside your HIPAA boundary, federate existing identities (Epic, Cerner, AD, Okta), and migrate discovered access policies.

5 days

Connect your estate across EHR, claims, policy admin, lab, imaging, RWE, and operational systems into one catalog. Go live with full PHI lineage and start shipping governed data products to clinical and payer teams.

5 weeks

Power production AI use cases. Turn on the semantic layer over FHIR and clinical vocabularies, agent-ready endpoints with PHI redaction, audit scaffolding, and human review against the priority workflow your CMO or COO is asking about every Monday.

A Tier-1 global bank replaces legacy Hadoop and funds its AI agenda with the savings.

Ten-plus years of credit, risk, and transaction history on a sprawling Hadoop estate. Every modernization proposal on the table demanded a multi-year rip-and-replace — right as the bank was rushing to stand up its first production AI use cases.

$30M+

Cloudera license costs eliminated

$100M+

Hardware savings via serverless

30 Apps

Modernized for AI in under 4 weeks

0

Data leakage outside governed boundary

The Result

NexusOne laid a composable layer right over existing Hadoop and warehouses. Existing workload persisted, HDFS migrated to Iceberg formats with automated utilities and Spark jobs continued to run while delivering an AI-ready data layer to power consumer LLM assistant use cases.

The bank is now zeroing out legacy Hadoop license spend, safely decommissioning obsolete hardware, and running production AI on a sovereign fabric.

Built for healthcare security, privacy, and regulatory compliance.

SOC 2 Type II certified

HITRUST certified

True multi-tenant isolation (compute, catalog, data)

ISO 27001 compliant

Full audit trails — 500+ audits/year at production customers

Cell-level & row-level encryption

FedRAMP / GovCloud deployment experience

OpenID Connect — zero Kerberos dependency

Data sovereignty & GDPR from a single control plane

HIPAA-ready

Agent permission impersonation (AI agents inherit user RBAC)

SOC 2 Type II certified

FedRAMP / GovCloud deployment experience

HITRUST certified

OpenID Connect — zero Kerberos dependency

True multi-tenant isolation (compute, catalog, data)

Data sovereignty & GDPR from a single control plane

ISO 27001 compliant

HIPAA-ready

Full audit trails — 500+ audits/year at production customers

Agent permission impersonation (AI agents inherit user RBAC)

Cell-level & row-level encryption

SOC 2 Type II certified

FedRAMP / GovCloud deployment experience

HITRUST certified

OpenID Connect — zero Kerberos dependency

True multi-tenant isolation (compute, catalog, data)

Data sovereignty & GDPR from a single control plane

ISO 27001 compliant

HIPAA-ready

Full audit trails — 500+ audits/year at production customers

Agent permission impersonation (AI agents inherit user RBAC)

Cell-level & row-level encryption

Your agents are already running. Is your data layer ready to govern them?

The payers, providers, and life sciences sponsors getting AI right aren't the ones with the best vendor demo. They're the ones who sorted out PHI lineage, audit trail, and agent governance before a regulator, a privacy officer, or a clinician forced the issue.

Keep what's working

Your EHR, claims, policy admin, legacy Hadoop, and cloud stay, without a multi-year migration that holds AI hostage.

Design for open, sovereign data

PHI stays inside your HIPAA perimeter so agents work without data ever crossing a vendor boundary.

Build in air-gapped, 360 Agent governance

FinOps, circuit breakers, PHI redaction, lineage, and a central agent registry from day one.

Get a Demo


Book your free strategy session with a NexusOne data consultant. We'll explore your current data estate and discuss how a composable, open data platform that wraps your existing infrastructure in a modern layer can deliver production outcomes in weeks, not years.



Get a Demo


Book your free strategy session with a NexusOne data consultant. We'll explore your current data estate and discuss how a composable, open data platform that wraps your existing infrastructure in a modern layer can deliver production outcomes in weeks, not years.



Get a Demo


Book your free strategy session with a NexusOne data consultant. We'll explore your current data estate and discuss how a composable, open data platform that wraps your existing infrastructure in a modern layer can deliver production outcomes in weeks, not years.



FAQs

How is this different from Snowflake or Databricks?

Both are proprietary destinations. We're an open layer that sits across them, plus your EHR, your claims platform, your policy admin, your Hadoop, and your on-prem clinical archives. Many health systems and payers run Snowflake or Databricks for analytics. We make the rest of the estate work alongside them, governed under one HIPAA and HITRUST envelope.

Why HIPAA and HITRUST and not just one?

HIPAA is the legal floor. HITRUST is how health plans, sponsors, and clinically integrated networks operationalize it across vendors. We carry both certifications so a payer, provider, or sponsor can deploy NexusOne against the highest healthcare-data compliance bar without a custom security review for every new use case.

Our PHI can't leave the building. How does AI work?

NexusOne runs inside your VPC, your data center, or your sovereign cloud. PHI never egresses. The model can sit inside the boundary. The weights stay inside the boundary. Agents run where the data is, not the other way around. Your PHI never becomes part of someone else's foundation model.

We already have an EHR-vendor AI module. Why add another layer?

EHR-vendor AI is good at the use cases the EHR vendor builds. It rarely reaches claims, policy admin, lab, imaging, RWE, or operational data, which is where most enterprise AI use cases actually live. NexusOne is the cross-estate layer that lets EHR-vendor AI, your own models, and third-party clinical models work over the same governed, HIPAA-grade fabric.

Why not have our own team build this on open source?

You can, but doing so takes at least 18–24 months, a sustained team of senior platform and security engineers, and a running tax on every upgrade, every Hadoop CVE, and every HIPAA control review. Health systems and payers can no longer afford that pace at AI-era speed. Our automation layer removes that tax so you keep the open-standards foundation without inheriting maintenance.

How does the cost compare to what we run today?

NexusOne provides simple vCore pricing in a fully managed solution with healthcare-scale discounting on top of rack rate. In most engagements, NexusOne provides cost savings against legacy Hadoop, ETL, and proprietary clinical-data platforms we help sunset, before counting the return on AI the platform enables.

ABOUT

1115 Howell Mill Rd
Suite 430,
Atlanta, GA 30318
An Insight Partners Company


Product Updates and News

@2026 NexusOne® - All rights reserved.

ABOUT

1115 Howell Mill Rd
Suite 430,
Atlanta, GA 30318
An Insight Partners Company


Product Updates and News

@2026 NexusOne® - All rights reserved.

ABOUT

1115 Howell Mill Rd
Suite 430,
Atlanta, GA 30318
An Insight Partners Company


Product Updates and News

@2026 NexusOne® - All rights reserved.